MAX300-BIO

Unmatched Mass Spec Technology for Bioreactor Monitoring Applications

Powerful Quadrupole Mass Spec Technology

Our EXTREL™ MAX300-BIO™ uses cutting edge quadrupole mass spectrometer technology to quantify bioreactor gases from multiple reactors within the facility and reports the data to the control system in real-time.

Quantitative analysis of individual contaminants
PPT detection limits
Analysis time in seconds
Measures CO2, O2, N2, H2O, alcohols, contaminants, and more
Samples without risk of contamination
Calculates control parameters in real-time (e.g. Respiratory Quotient)
Provides flow and mass balance data
Multiport sample systems for up to 80+ reactors
High precision and accuracy for optimal process automation
Low maintenance, utilities and calibration required
Complete method scale-up
Lab, Pilot, Production

Delivers Real-Time Process Control with 24-7 bioreactor monitor with a documented uptime >98%

Calculated Control Loop inputs using the effluent composition, the MAX300-BIO calculates the key indicators of organism health and process efficiency:

Carbon Dioxide Evolution Rate (CER)
Oxygen Uptake Rate (OUR)
Respiratory Quotient (RQ)
Total Gas Flow
Total Mass Balance
Liquid Concentrations in the vessel
Batch Quality – Analysis of minor ppm/ppb level components such as formaldehyde, methanol, acetic acid, etc.
Gases Measured: CO2, O2, N2, H2O, argon, ethanol, methanol, formaldehyde, others

The MAX300-BIO Bioreactor Gas Analyzer and MAX300-RTG 2.0 Industrial Gas Analyzer have been installed in major manufacturing stages within pharmaceutical industries. One of the main applications is fermentation process control. In the fermentation process, the growth of bacteria and production of drugs takes place under very tight conditions. The aeration rate, temperature and dosage of nutrients are regulated very closely during several stages of the process. The Quadrupole Mass Spectrometer is used to provide full, fast and precise analysis of the incoming air and the off gas from the fermenter.

The results are used to calculate the Respiratory Quotient (RQ), a major parameter in controlling growth and health of the bacteria. In different stages of a batch fermentation process, the RQ value changes, thus allowing for optimum and efficient drug production. The additional analysis of minor concentrations of by-products allow for rapid process adjustment to avoid undesired reactions. One MAX300-BIO Bioreactor Gas Analyzer is capable of analyzing up to 80 samples with the use of a single FAST multi-port valve. This multi-stream capability makes the Extrel MAX300-BIO the economical alternative to infrared and oxygen analyzers installed on top of each fermenter.