Our MAX300-BIO™ Bioreactor Mass Spectrometer Gas Analyzers have been installed in major manufacturing stages across the pharmaceutical industry worldwide. One of its main applications is Fermentation process control.   This quadrupole, economical, high-performance solution was designed for PAT in fermentation control applications.

• Ability to monitor multiple components in multiple streams, speed of response, parts per billion (ppb) detection limit and flexible analysis will help you improve your fermentation control
• Can analyze one component in approximately 400 milliseconds: one full sample analysis in less than 10 seconds
• Continuous monitoring of the bioreaction process gives the operator a full understanding of the health of the culture and the efficiency of the process
• Has a dynamic range of 100% down to 10 ppb to allow you to quickly adjust the process without comprising the batch quality
• Capable of analyzing up to 80 samples with the use of a single FAST multi-port valve
• Economical alternative to infrared and oxygen analyzers installed on top of each Fermenter

Our MGA 1200 CS™ Fixed Magnet Mass Spectrometer is ideal for Microbial Fermentation & Mammalian Cell Culture analysis.  The MGA is capable of monitoring multiple fermenters and/or bioreactors with a single MGA1200CS (up to 99).

• Precise measurement of RQ during both growth and productive phases of microbial fermentation
• Ensures viable cell density is achieved prior to transition to productive phase
• Precise measurement of RQ during both growth and productive phases of microbial fermentation
• Ensures viable cell density is achieved prior to transition to productive phase
• Monitor important indicators of limiting conditions
• Report DO2 probe drift c/o oxygen mass transfer (Kla)
• Seamlessly perform Effluent Gas Analysis for:  Nitrogen %, Oxygen %, Argon %, CO2 %, and Derived Values (RQ, CER, OUR)

In the fermentation process, the growth of bacteria and production of drugs takes place under very tight conditions. The aeration rate, temperature and dosage of nutrients are regulated very closely during several stages of the process. The Quadrupole Mass Spectrometer is used to provide full, fast and precise analysis of the incoming air and the off-gas from the Fermenter. The results are used to calculate the Respiratory Quotient (RQ), a major parameter in controlling growth and health of the bacteria. In different stages of a batch fermentation process, the RQ value changes, thus allowing for optimum and efficient drug production. The additional analysis of minor concentrations of by-products allows for rapid process adjustment to avoid undesired reactions.