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Pharmaceuticals, Life Science & Biotechnology

ANALYTICAL Solutions for Pharmaceuticals, Life Science & Biotechnology

The pharmaceutical, life science, and biotechnology sectors remain vital components of healthcare systems globally. To establish a strong presence in the market, pharmaceutical manufacturers must embrace the most advanced and groundbreaking technologies. Over time, these industries have consistently played a crucial role in healthcare systems worldwide. In today’s dynamic landscape, manufacturers must stay informed about the latest advancements in Process Analytical Technologies (PAT). By adopting innovative and state-of-the-art technologies, pharmaceutical manufacturers equip themselves with the necessary tools to succeed and thrive in the marketplace.

We know your process and how critical it is for you to protect precious and limited resources.


Get the most reliable, most precise gas analysis technologies available on the market today.  We will work to match your needs and budget and provide the optimal, and most stable process analysis solution for your application. 

Need help? No problem.  We’re here to help.  Contact us today.



Real-Time Toxic Gas Monitoring Solution in Ambient Air

Our NEW EXTREL™ MAX300-TGM™ Toxic Gas Monitor is a real time monitoring solution with analysis speeds of 0.4 seconds per chemical and gas clearing times of less than 3 seconds.  These impressive speeds exceed industry requirements for continuous monitoring. With the ability to analyze 15+ chemicals per sample point, the MAX300-TGM toxic gas analyzer provides maximum efficiency at an extremely low cost-per-chemical, per sample point. 

MAX300-TGM Advantages Include:

  • Versatile and flexible analyzer – detect multiple chemicals on up to 46 sample points
  • Fast measurement with high sensitivity, reducing false alarms
  • Highly responsive to changes in chemical concentration – reducing down time after an event
  • Streamlined operation – centralized analyzer for full facility monitoring
  • Low cost of ownership and streamlined operation – decreasing complexity in maintenance and upkeep
  • Industry leading application expertise and technical support with decades of experience with ambient air monitoring
  • Large, user-friendly touch screen interface for at-a-glance updates with customizable alarm verifications


    Breath analysis is a non-invasive diagnostic technique that involves analyzing the composition of a person’s exhaled breath. It has become an increasingly popular method of diagnosing a variety of conditions, including infectious diseases, cancer, and metabolic disorders. One of the primary tools used in breath analysis is mass spectrometry.

    Our EXTREL™ quadrupole mass spectrometry is a powerful technique that can be used in breath analysis to detect and identify volatile organic compounds (VOCs) present in human breath.


    Evolved Gas Monitoring is an analytical technique used to study the thermal or chemical decomposition of a material by monitoring the gases released during the process. It typically involves coupling a thermal analyzer, such as a thermogravimetric analyzer, with a gas analysis system, such as mass spectrometry, Fourier-transform infrared spectroscopy (FTIR), or gas chromatography.

    Our solutions also include:

    • CRDS Trace-Level, Low-Pressure Moisture Analyzer TIGER OPTICS™ HALO RP/QRP™
    • CRDS Ambient-Pressure Analyzer for Trace HCl, NH3, HF, CO and CH4 TIGER OPTICS™ T-I Max™
    • CRDS Trace Gas Analyzer for ppb-Level of H2O, CH4, CO, CO2, and C2H2 Detection TIGER OPTICS™ Spark™
    • Benchtop Mass Spectrometer with Heated, Evolved-Gas Inlet for Real- Time, Continuous Off-gas Analysis EXTREL™ MAX300-EGA™

    In the fermentation process, growing bacteria and production of drugs occurs.  Fermentation has three stages:  Primary fermentation, secondary fermentation, and bottle or keg conditioning and carbonation.  The fermentation process is used for the production of biomass, enzymes, chemicals and pharmaceuticals. Cell types used in these culture processes were traditionally yeasts, fungi and bacteria. 

    The fermentation process is a complex biological process that involves the conversion of organic materials, such as sugars, into useful products such as biofuels, pharmaceuticals, and biopolymers. The efficiency and quality of the fermentation process can be greatly improved by monitoring the process parameters in real-time, and this is where mass spectrometry comes in.

    Our EXTREL™ Quadrupole Mass Spectrometer is often used to provide full, fast and precise analysis of the incoming air and the off gas from the fermenter. The results are used to calculate the Respiratory Quotient (RQ), a major parameter in controlling growth and health of the bacteria. In different stages of a batch fermentation process, the RQ value changes, thus allowing for optimum and efficient drug production. The additional analysis of minor concentrations of by-products allows for rapid process adjustment to avoid undesired reactions.

    Use our MGA™ fixed magnetic sector mass spectrometer to analyze gas samples in fermentation processes to monitor and control the process.  The fixed magnetic sector mass spectrometer can be used to detect and quantify a wide range of gas species, including carbon dioxide, oxygen, nitrogen, and other volatile organic compounds (VOCs). In fermentation processes, the mass spectrometer can be used to monitor the metabolic activity of microorganisms, measure nutrient uptake, and detect contamination.

    Our solutions also include:

    • Real-Time, Multi-Stream Mass Spectrometer Gas Analyzer for Accurate OUR, CER and RQ MGA 1200CS™
    • Benchtop Mass Spectrometer for Real-Time Multi-Stream, Bioreactor Control MAX300-LG™
    • CRDS Single-Species, Trace G, as Analyzer for ppb-Level H2O,   CH4,  CO, CO2, Detection Spark™  

    Glove boxes, also known as glove chambers or isolation glove boxes, are highly specialized enclosures that are widely used in ultra-pure environments where the presence of oxygen, water vapor, and dust can cause contamination and affect the quality of the products being produced.  This includes lithium-ion batteries and materials, semiconductors, pharmaceutical, super capacitors, special lamps, laser welding, brazing, material synthesis, and OLED, MOCVD.  Continuous measurement of oxygen levels in glove boxes is necessary for pure environments and controlled atmospheres. Even though the glove box environment is intended to be closed.  Yet small amounts of oxygen can seep through the glove ports. Glove box oxygen deficiency monitors are designed for these enclosures using nitrogen or cryogenics.

    Our solutions also include:

    • Trace to Percent Oxygen Monitors for Portable and Fixed Applications ALPHA OMEGA INSTRUMENTS™ Series 3520™ and OXY-SEN™
    • Aluminum Oxide Dew Point Meters & Transmitters with Hyper-Thin-Film Technology for Portable/Fixed/Loop-Powered Applications COSA XENTAUR™ XDT™ | XPDM™ | LPDT2™
    • CRDS Trace Gas Analyzer for ppb-Level Detection of H2O,  CH4,CO,CO2 and C2H2  Spark™
    • Laboratory Mass Spectrometers for Real-Time, ppb-level, Multi- Impurity Analysis EXTREL™ MAX300-LG™
    • Benchtop Mass Spectrometer for Real-Time ppb-Level to 100% Catalysis, Reaction Monitoring, and Environmental Research EXTREL™ MAX300-CAT™
    • Chilled Mirror Dew Point Hygrometer with Measuring Head for Temperature and RH Measurements MBW™ Model 973™

    Our solutions include:


    Process Analytical Technologies (PAT) is an approach used in manufacturing and process industries to monitor and control the production process in real-time. It involves the use of advanced analytical techniques to monitor the various process parameters and ensure that the product is being manufactured consistently and to the desired quality standards.

    Our quadrupole mass spectrometers can detect even trace amounts of impurities or reaction intermediates and provide real-time feedback to the process control system. This information can then be used to adjust the process parameters, such as the flow rate or temperature, in order to optimize the process and ensure consistent product quality.

    Our MGA™ fixed magnetic sector mass spectrometer is another powerful analytical tool that can be used in a wide range of Process Analytical Technologies applications.  The mass spectrometer is particularly useful in PAT applications because it is a highly accurate and precise analytical tool. It can detect and quantify trace amounts of chemical species with high sensitivity and specificity, making it ideal for quality control and process optimization in a wide range of industries.  It is capable of detecting and quantifying a wide range of chemical species in real-time. Its high accuracy and precision make it an essential tool for process monitoring and control in many industries.


    Secondary Ion Mass Spectrometry (SIMS) is used to detect and characterize trace elements at or near the surface of a solid or thin film allowing researchers to understand the chemical composition of the surface.   This surface science technique requires the use of systems with very high sensitivity and the ability to perform high resolution energy analysis. SIMS is useful for a wide variety of surface analysis. For example, SIMS can be used to detect and analyze contaminants on a surface, analyze materials and devices to ensure the quality of specific products, and study atomic scale defects that may occur in the manufacturing of semiconductor chips or other materials. 

      Our EXTREL™ MAX-QMS™ Mass Spectrometer System has the performance and flexibility required for these applications. The MAX-QMS systems are the highest performance quadrupole analyzers available. Coupled with one of our high transmission Energy Filters, the MAX-QMS systems furnish the high performance necessary for high accuracy surface analysis and depth profiling.


      Pharmaceutical manufacturers are well aware of the industry statistics that at least 25% of time and energy can be saved by terminating the active pharmaceutical ingredient drying process at its true endpoint. However, actually determining the true endpoint has always been an obstacle. To avoid interrupting the process (traditional methods to determine the drying process involved sampling and analyzing the product in a lab) and possible contamination of an entire batch, many producers choose to overextend the drying process.

      Today’s engineers can solve this problem by using our EXTREL™ MAX300-RTG 2.0 Industrial Gas Analyzer or the MAX300-LG Laboratory Gas Analyzer. Both can monitor the atmosphere composition above the drying material. Because the headspace is in close relationship with the concentration of solvents in the material, the true drying process end point can be determined by analyzing the headspace vapors. Our quadrupole mass spectrometers allow you the ability to view the concentration profiles of solvents over time, pinpointing the exact moment the drying is complete.  With its dual detector and dynamic auto ranging capabilities, the MAX300 has a detection range of 100% to 10 parts per billion.  

      Our solutions also include:

      • Industrial Mass Spectrometer for Real-Time, Multi-Stream, Solvent Drying and Endpoint Determination EXTREL™ MAX300-BIO™
      • Benchtop Mass Spectrometer for Real-Time, Multi-Stream, Solvent Drying and Endpoint Determination EXTREL™ MAX300-LG™
      • CRDS Trace-Level, Low-Pressure Moisture Analyzer for Lyophilization TIGER OPTICS™ HALO RP/QRP™

      Thermogravimetric analysis (TGA) is a powerful analytical technique that can be used to study the thermal behavior of solid and liquid samples. TGA measures the change in weight of a sample as a function of temperature or time under controlled heating conditions. This technique can provide valuable information about the thermal stability, composition, and degradation of a sample.

      TGA is a versatile technique that can be used to study a wide range of samples, including solids, liquids, and gases. It is a non-destructive method that requires only small amounts of sample, making it a valuable tool for materials characterization and quality control. TGA can be used in conjunction with other analytical techniques, such as Fourier-transform infrared spectroscopy (FTIR) or mass spectrometry (MS), to provide additional information about the composition and structure of the sample.

      Our EXTREL™ MAX300-EGA evolved gas analyzer comes equipped to import a Start-of-Heating signal from the TGA for easy data synchronization and features a chemically inert transfer line specially designed keep the sample hot and under vacuum all the way to the ionizer, to guard against condensation or chemical interaction.


      The requirements for water analysis in pharmaceutical manufacturing, biotechnology and life science is high. Besides ensuring high product quality, process safety and reliability are important objectives.  Pharmaceutical water in particular places high demands on the accuracy of online analysis, since the water quality of e.g. water for injection is decisive for the product quality. For the compliance of the water quality there are standards as well as pharmaceutical standards (pharmacopoeia), which define the requirements for such pharmaceutical water, such as water for injection (WFI) and ultra-pure water (UPW).

      In the pharmaceutical industry, purified water is an essential component used in the manufacturing and testing of pharmaceutical products. Pure water is a highly purified form of water that is free of impurities and contaminants, such as microorganisms, dissolved solids, and organic and inorganic substances, that may interfere with the quality, safety, and efficacy of pharmaceutical products.

      Our solutions include:

      • TOC Water Analyzer for Harsh Wastewater Applications LAR™ QuickTOCultra
      • TOC Water Analyzer for Clean Water Applications LAR™ QuickTOCuvll
      • TOC Water Analyzer for Municipal and Cooling Water Applications LAR™ QuickTOCeco
      • COD Water Analyzer for Laboratories LAR™ QuickCODlab

      Our solutions include:


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