The MAX300-BIO is an advanced bioprocess gas analyzer designed for continuous monitoring of fermentation, microbial cultivation, mammalian cell culture, and biopharmaceutical manufacturing. Unlike conventional off-gas sensors that measure only oxygen and carbon dioxide, the MAX300-BIO simultaneously analyzes multiple gases in real time, providing comprehensive process intelligence for improved bioreactor control.

Using proven quadrupole mass spectrometry, the MAX300-BIO continuously measures process gases while automatically calculating Oxygen Uptake Rate (OUR), Carbon Dioxide Evolution Rate (CER), and Respiratory Quotient (RQ) to optimize yields, reduce batch variability, and support Process Analytical Technology (PAT) initiatives.  Contact us today.

One MAX300-BIO Bioreactor & Fermentation Quadrupole Mass Spectrometer is capable of analyzing up to 80 samples with the use of a single FAST multi-port valve.  Accurate off-gas analysis tells the control loop exactly what is happening inside each reactor without the risks involved with probes or manual sampling.

calculates the key indicators of organism health and process efficiency

• Carbon Dioxide Evolution Rate (CER)
• Oxygen Uptake Rate (OUR)
• Respiratory Quotient (RQ)
• Total Gas Flow
• Total Mass Balance
• Liquid Concentrations in the vessel
• Batch Quality – Analysis of minor ppm/ppb level components such as formaldehyde, methanol, acetic acid, etc.
• Gases Measured: CO₂, O₂, N₂, HVO, argon, ethanol, methanol, formaldehyde, AND others

Why Choose a Process Insights Process Mass Spectrometer?

Why Monitor Bioreactor Off-Gas?

Real-time off-gas analysis provides immediate insight into cellular metabolism, microbial growth, substrate utilization, and process performance.

Continuous gas monitoring helps operators:

• Optimize fermentation performance
• Increase product yields
• Shorten development cycles
• Reduce batch failures
• Detect process deviations immediately
• Improve scale-up success
• Automate process control
• Support Quality by Design (QbD)
• Meet PAT requirements