Unmatched Mass Spec Technology for Bioreactor Monitoring Applications

Powerful Mass Spec Technology

Mass Spectrometry is a powerful tool for bioreactor monitoring. Changes to the composition of bioreactor or fermenter off-gas provide crucial insight into cellular health and production efficiency. This makes the fast, accurate analysis of CO2, O2, N2, Ar, H2O and other compounds essential for real-time process control.  Our MAX300-BIO uses cutting edge quadrupole mass spectrometer technology to quantify bioreactor gases from multiple reactors within the facility and reports the data to the control system in real-time. 


  • Quantitative analysis of individual contaminants
    PPT detection limits
  • Analysis time in seconds
  • Measures CO2, O2, N2, H2O, alcohols, contaminants, and more
  • Samples without risk of contamination
  • Calculates control parameters in real-time (e.g. Respiratory Quotient)
  • Provides flow and mass balance data
  • Multiport sample systems for up to 80+ reactors
  • High precision and accuracy for optimal process automation
  • Low maintenance, utilities and calibration required
  • Complete method scale-up
  • Lab, Pilot, Production

MAX300-BIO Delivers Real-Time Process Control |  a 24-7 bioreactor monitor with a documented uptime >98%

Accurate off-gas analysis tells the control loop exactly what is happening inside each reactor without the risks involved with probes or manual sampling.

Calculated Control Loop inputs using the effluent composition, the MAX300-BIO calculates the key indicators of organism health and process efficiency:

  • Carbon Dioxide Evolution Rate (CER)
  • Oxygen Uptake Rate (OUR)
  • Respiratory Quotient (RQ)
  • Total Gas Flow
  • Total Mass Balance
  • Liquid Concentrations in the vessel
  • Batch Quality – Analysis of minor ppm/ppb level components such as formaldehyde, methanol, acetic acid, etc.
  • Gases Measured: CO2, O2, N2, H2O, argon, ethanol, methanol, formaldehyde, others

The Extrel MAX300-BIO Bioreactor Gas Analyzer and MAX300-RTG 2.0 Industrial Gas Analyzer have been installed in major manufacturing stages within pharmaceutical industries. One of the main applications is fermentation process control.  In the fermentation process, the growth of bacteria and production of drugs takes place under very tight conditions. The aeration rate, temperature and dosage of nutrients are regulated very closely during several stages of the process. The Quadrupole Mass Spectrometer is used to provide full, fast and precise analysis of the incoming air and the off gas from the Fermentor. The results are used to calculate the Respiratory Quotient (RQ), a major parameter in controlling growth and health of the bacteria. In different stages of a batch fermentation process, the RQ value changes, thus allowing for optimum and efficient drug production. The additional analysis of minor concentrations of by-products allow for rapid process adjustment to avoid undesired reactions.  One MAX300-BIO Bioreactor Gas Analyzer is capable of analyzing up to 80 samples with the use of a single FAST multi-port valve. This multi-stream capability makes the Extrel MAX300-BIO the economical alternative to infrared and oxygen analyzers installed on top of each Fermentor.

For a complete range of system options, please contact us.


Americas +1 412.963.7530 
EMEA +49 69 20436910
China/APAC +86 400 086 0106

    Perfect for Bioreactor and Fermentation Applications Requiring Real-Time, Continuous Monitoring

    Process Inisights_Extrel MAX300-BIO


    • Biofuels
    • Ethanol
    • Pharmaceutical Products
    • Enzymes
    • Antibiotics
    • Steroids
    • Vitamins
    • Biomass
    • Biopolymers
    • Alcoholic Beverages
    • Bread Products
    • Waste Treatment

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