Mass Spectrometry is a powerful tool for bioreactor monitoring. Changes to the composition of bioreactor or fermenter off-gas provide crucial insight into cellular health and production efficiency. This makes the fast, accurate analysis of CO2, O2, N2, Ar, H2O and other compounds essential for real-time process control. Our EXTREL™ MAX300-BIO™ bioreactor monitor gas analyzer uses cutting edge quadrupole mass spectrometer technology to quantify bioreactor gases from multiple reactors within the facility and reports the data to the control system in real-time. One MAX300-BIO bioreactor monitor gas analyzer is capable of analyzing up to 80 samples with the use of a single FAST multi-port valve. Accurate off-gas analysis tells the control loop exactly what is happening inside each reactor without the risks involved with probes or manual sampling.
The MAX300-BIO bioreactor monitor gas analyzer is a powerful analytical instrument designed for monitoring the gases produced and consumed during biological fermentation processes. Here are some of the benefits:
The MAX300-BIO Bioreactor Gas Analyzer and MAX300-RTG 2.0 Industrial Gas Analyzer have been installed in major manufacturing stages within pharmaceutical industries. One of the main applications is fermentation process control. In the fermentation process, the growth of bacteria and production of drugs takes place under very tight conditions. The aeration rate, temperature and dosage of nutrients are regulated very closely during several stages of the process. The Quadrupole Mass Spectrometer is used to provide full, fast and precise analysis of the incoming air and the off gas from the Fermenter.
The results are used to calculate the Respiratory Quotient (RQ), a major parameter in controlling growth and health of the bacteria. In different stages of a batch fermentation process, the RQ value changes, thus allowing for optimum and efficient drug production. The additional analysis of minor concentrations of by-products allows for rapid process adjustment to avoid undesired reactions. This multi-stream capability makes the MAX300-BIO the economical alternative to infrared and oxygen analyzers installed on top of each Fermenter.
The MAX300-BIO bioreactor monitor gas analyzer is designed for use in the biopharmaceutical industry, specifically for monitoring the gas composition in bioreactor vessels during the production of biologics and other biological products. Some of the industries that use the MAX300-BIO™ bioreactor monitor gas analyzer include:
• Alcoholic Beverages
• Bread Products
• Waste Treatment
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