Skip to main content

Bioprocess Monitoring & Off-Gas Analysis for Life Sciences

Bioprocess Monitoring & Off-Gas Analysis for Life Sciences

Process Insights provides advanced bioprocess monitoring, off-gas analysis, and bioreactor analytics solutions for pharmaceutical, biotechnology, and life sciences manufacturers. Our technologies support cell culture monitoring, fermentation monitoring, and PAT analytics by delivering continuous, real-time measurement of critical process gases and biological activity.

With industry-leading mass spectrometry, spectroscopy, and gas analysis technologies, manufacturers gain actionable process insights that improve product quality, increase yields, reduce batch variability, and accelerate scale-up from laboratory development to commercial production. Process Insights solutions help organizations implement effective bioprocess control, enabling faster decision-making and greater confidence throughout the manufacturing lifecycle.

Process Insights solutions support critical applications including Process Analytical Technologies (PAT), cell culture monitoring, and fermentation processes, helping manufacturers implement:

  • Advanced spectroscopy and gas analysis techniques
  • Real-time process monitoring and control
  • Improved product quality and batch consistency
  • Streamlined production and reduced operational costs
  • Enhanced regulatory compliance and risk management
  • Faster development and time-to-market for new therapies
  • Greater collaboration through reliable process data and insights

By delivering precise analytical solutions and trusted instrumentation, Process Insights empowers life sciences manufacturers to optimize processes, ensure product safety, and accelerate innovation.

Process Insights manufactures advanced process analyzers, gas analysis systems, and water monitoring solutions trusted worldwide in refining, oil & gas, petrochemicalchemical, semiconductorlife sciences, and other industrial segments.   

We manufacture the brands you know and trust:  ATOM, EXTREL, GUIDED WAVE, COSA XENTAUR, TIGER OPTICS, LAR, MBW, and more.

How to Choose the Right Gas Analysis System for Your Application

Off-Gas Analysis for Fermentation Monitoring and Cell Culture Monitoring

Off-gas analysis is one of the most powerful tools available for understanding biological activity inside fermenters and bioreactors. By continuously measuring oxygen consumption and carbon dioxide production, manufacturers gain real-time visibility into metabolic activity, culture health, and process performance.

Process Insights solutions support:

  • Fermentation off-gas analysis
  • Bioreactor off-gas monitoring
  • Cell culture process monitoring
  • Continuous gas monitoring
  • Gas composition analysis
  • Online process analytics
  • Real-time bioprocess control

Continuous monitoring reduces reliance on manual sampling while providing faster, more accurate process insights that improve operational efficiency and product consistency. Real-time off-gas monitoring is widely used to characterize fermentation and cell culture processes while supporting process optimization and yield improvement.

LIFE SCIENCES SOLUTIONS

Fermentation Cell Culture

MGA 1200CS Fixed Magnetic MS

Bring products to market quicker with the highest precision for OUR/CER/RQ calculations

Solvent Drying Lyophilization

MAX300-BIO Series Quadrupole MS

Maximize your product throughput with accurate solvent endpoint determination

Toxic Gas Measurements

MAX300-TGM Quadrupole MS

Protect your worker’s safety with accurate and reliable, multiple sample point gas monitoring

Solvent Measurements

NIR-O & 508 UV-Vis | Dispersive NIR / UV-Vis

Increase API production by using an industrial spectrometer designed for use in classified areas

Vapor Hydrogen Peroxide Monitoring

ClearView db Dispersive NIR

Ensure your products have received the correct exposure to Vapor Hydrogen Peroxide by direct measurement

Trace Ethylene Oxide Monitoring

T-I Max EtO CRDS

Delivers continuous, real-time monitoring of ethylene oxide (EtO) using advanced Cavity Ring-Down Spectroscopy (CRDS) technology


What is Bioprocess Monitoring?

Bioprocess monitoring is the continuous measurement and analysis of critical process parameters during fermentation, cell culture, and biopharmaceutical manufacturing. Real-time monitoring allows operators to understand biological activity, optimize process conditions, and maintain consistent product quality.

Process Insights solutions enable:

  • Real-time bioprocess monitoring
  • Continuous fermentation monitoring
  • Cell culture monitoring
  • Online gas analysis
  • Bioreactor analytics
  • Process optimization and control
  • Scale-up optimization
  • Process Analytical Technology (PAT) implementation

Modern bioprocessing facilities rely on real-time process data to improve manufacturing efficiency, increase yields, and support regulatory compliance through enhanced process understanding. PAT initiatives increasingly emphasize real-time monitoring and control of critical process parameters and quality attributes.

OUR, CER & RQ Monitoring for Bioreactor Analytics

Process Insights analytical technologies enable precise measurement of critical respiratory indicators used throughout upstream bioprocessing.

Oxygen Uptake Rate (OUR)

Monitor oxygen consumption to evaluate culture activity, optimize aeration strategies, and improve process performance.

Carbon Evolution Rate (CER)

Measure carbon dioxide production to track metabolic activity and assess fermentation progress in real time.

Respiratory Quotient (RQ)

Utilize RQ calculations to gain deeper insight into cellular metabolism and optimize feeding strategies.

OUR, CER, and RQ monitoring provide essential process intelligence for fermentation monitoring, cell culture monitoring, and scale-up optimization. These metrics are commonly used in advanced bioprocess analytics and off-gas analysis applications.

Learn how our EXTREL Mass Spec works in the Analysis of Acetonitrile in Ambient Air

Life safety and monitoring Dichloromethane in Ambient Air with our EXTREL Mass Spec

Process Insights has a broad portfolio of analytical solutions for Life Sciences and the Pharmaceutical Industries


FEATURED PRODUCTs

Sample Interfaces & Flowcells

Real-time optical analysis is only as strong as the interface between your analyzer and the process. Our GUIDED WAVE™ Sample Interfaces from Process Insights are rugged, precision-engineered probes and flow cells act as the critical “window into the process,” delivering reliable, high-quality spectral data even in the most demanding environments.

✔ Rugged, Reliable Design
✔ Exceptional Optical Performance
✔ Versatile Configurations
✔ Easy Maintenance & Integration
✔ Industry-Ready Solutions

With sample interfaces that deliver consistent optical alignment and robust path length stability, your spectroscopy system will run more reliably and deliver higher-quality data for critical process control, QA/QC, and research applications.

Explore the full range of GUIDED WAVE Probes & Flow Cells and upgrade your optical measurement performance today!


Fermentation Control in Life Sciences and Bioprocessing

Fermentation, a process critical to life sciences.  It involves the growth of bacteria and the production of drugs. It consists of three stages: primary fermentation, secondary fermentation, and bottle or keg conditioning and carbonation. This process is widely used to produce biomass, enzymes, chemicals, and pharmaceuticals. Traditionally, yeast, fungi, and bacteria have been the primary cell types used in fermentation.

To Top

Process Analytical Technologies (PAT) in Pharmaceuticals, Life Science and Biotechnology

Process Analytical Technologies (PAT) is a strategy employed in manufacturing and process industries to monitor and control production in real-time. By utilizing advanced analytical techniques, PAT ensures that process parameters are continually monitored to guarantee that products are consistently manufactured to meet the desired quality standards in pharmaceuticals, life science, and biotechnology.