Optimize Processes | Ensure Compliance | Improve Product Quality with Process Analytical Technology (PAT)
Pharmaceutical, biotechnology, and life sciences manufacturers are increasingly adopting Process Analytical Technology (PAT) to support continuous manufacturing and Quality by Design (QbD) initiatives. PAT enables real-time, in-line monitoring and control of critical process parameters (CPPs) and critical quality attributes (CQAs)—driving efficiency, improving product quality, and ensuring regulatory compliance with global standards including FDA, EMA, and ICH guidelines (Q8–Q11).
Real-Time Gas Analysis with MGA 1200CS
The Process Insights MGA 1200CS™ Fixed Magnetic Mass Spectrometer delivers ultra-fast, multi-component gas analysis with enhanced precision, robustness, and real-time data, enabling greater control over pharmaceutical and biopharmaceutical processes.
MGA 1200CS, a high-performance process mass spectrometer, offers advanced multi-stream gas analysis in real time. Its rapid, accurate monitoring supports FDA 21 CFR Part 11 compliance (Electronic Records) optimizes process validation and enables real-time release testing (RTRT)-helping manufacturers reduce cycle times and enhance product consistency.
Key Features & Benefits
- Fast, Real-Time Gas Analysis – Provides near-instantaneous results for enhanced process control
- Supports Continuous Manufacturing – Enables efficient, uninterrupted production
- Regulatory Compliance – Ensures adherence to FDA, EMA, ICH Q8-Q11, cGMP standards
- Data Integrity & Compliance – Meets FDA 21 CFR Part 11 electronic recordkeeping requirements
- Advanced Chemometrics & MVDA – Supports predictive analytics and process modeling
- Versatile & Reliable – Ideal for monitoring NIR, UV-Vis, and spectroscopy applications
- Enhanced Sensitivity & Selectivity – Provides superior accuracy in multi-gas detection
- Robust & Low Maintenance – Engineered for durability and long-term operational stability
Our MGA 1200CS Fixed Magnetic Mass Spectrometer is ideal for Microbial Fermentation & Mammalian Cell Culture analysis. The MGA is capable of monitoring multiple fermenters and/or bioreactors with a single MGA1200CS (up to 99).
- Precise measurement of RQ during both growth and productive phases of microbial fermentation
- Ensures viable cell density is achieved prior to transition to productive phase
- Precise measurement of RQ during both growth and productive phases of microbial fermentation
- Ensures viable cell density is achieved prior to transition to productive phase
- Monitor important indicators of limiting conditions
- Report DO2 probe drift c/o oxygen mass transfer (Kla)
- Seamlessly perform Effluent Gas Analysis for: Nitrogen %, Oxygen %, Argon %, CO2 %, and Derived Values (RQ, CER, OUR)
The MGA 1200CS Fixed Magnetic Mass Spectrometer is equipped with advanced infrared (IR) and paramagnetic sensors, it delivers precise measurements of CO₂ and O₂, enabling real-time process adjustments that enhance efficiency and yield.
In addition to its analytical performance, the MGA 1200CS is engineered for ease of integration into existing fermentation systems. Its robust design ensures long-term durability in demanding environments, while its low-maintenance operation minimizes downtime and operational costs. Whether used in pharmaceutical bioprocessing, ethanol production, or food fermentation, the MGA 1200CS provides the data-driven insights needed to enhance process control, improve batch consistency, and drive operational excellence.
MGA 1200CS: Optimize Microbial Fermentation & Mammalian Cell Culture
MAX300-BIO: Complete, Fast & Precise Analysis of Incoming Air & Off-Gas from the Fermenter
