Off-Gas Analysis for Fermentation Monitoring and Cell Culture Monitoring
Off-gas analysis is one of the most powerful tools available for understanding biological activity inside fermenters and bioreactors. By continuously measuring oxygen consumption and carbon dioxide production, manufacturers gain real-time visibility into metabolic activity, culture health, and process performance.
Process Insights solutions support:
- Fermentation off-gas analysis
- Bioreactor off-gas monitoring
- Cell culture process monitoring
- Continuous gas monitoring
- Gas composition analysis
- Online process analytics
- Real-time bioprocess control
Continuous monitoring reduces reliance on manual sampling while providing faster, more accurate process insights that improve operational efficiency and product consistency. Real-time off-gas monitoring is widely used to characterize fermentation and cell culture processes while supporting process optimization and yield improvement.
What Can Be Measured?
Unlike conventional CO₂/O₂ analyzers, Process Insights systems simultaneously measure multiple gases from a single analyzer.
Typical gases include
- Oxygen (O₂)
- Carbon Dioxide (CO₂)
- Nitrogen (N₂)
- Argon
- Hydrogen
- Methane
- Water Vapor
- Additional process gases
Derived calculations include:
- Oxygen Uptake Rate (OUR)
- Carbon Dioxide Evolution Rate (CER)
- Respiratory Quotient (RQ)
- Gas utilization efficiency
- Metabolic activity trends
SALES | TRAINING INQUIRIES
AMERICAS: info.americas@process-insights.com
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CHINA: info.cn@process-insights.com
Fixed Magnetic Sector Mass Spectrometer
MGA 1200CS™
- Up to 99–100 bioreactors
- Simultaneous analysis of up to 16 gases
- New analytical data approximately every 3 seconds
- Low-flow sampling for small bioreactors
- Automatic OUR, CER, and RQ calculations
- CyberSecure Industry 4.0 architecture
- Optimize microbial fermentation
- Improve mammalian cell culture performance
- Detect metabolic changes immediately
Quadrupole Mass Spectrometer
MAX300-BIO™
- Laboratory research
- Process development
- Pilot-scale fermentation
- Production fermenters
- PPT detection limits
- Analysis time in seconds
- Multiport sample systems for total site monitoring