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Solvent Drying & Recovery

Enhance Solvent Drying & Recovery with Precision Gas Analysis

  • Maximize production efficiency and reduce solvent waste through accurate, real-time monitoring.
  • Easily switch between multiple chambers or drying systems, even when using different solvents.
  • Optimized for ambient pressure, vacuum drying, and lyophilization processes.
  • Perform trace moisture detection and multi-species analysis of solvents such as IPA, MEK, DCM, ethyl acetate, styrene, and acetonitrile.

Solvent Drying & Recovery & Mass Spectrometry

Due to the large number of chemical solvents used in the drying process, Quadrupole Mass Spectrometry is the only viable and economical analytical technology for Solvent Recovery applications. To achieve the flexibility of analysis and parts per billion detection (ppb) limits, the EXTREL™ MAX300-RTG™ Industrial Gas Analyzer is the system of choice.

Our online Quadrupole Mass Spectrometer System is capable of fast and flexible analysis of an unlimited number of compounds in a single analytical method. The selection and tuning of analysis masses is achieved through software, not hardware. Therefore, a pharmaceutical plant’s solvent recovery process can be streamlined with no idle time between batches. Additionally, this same system is capable of analyzing the final gas exhausted to the atmosphere to monitor plant compliance with environmental regulations.

Name Description IonA IonB IonC IonD
2-MeTHF 2-Methyltetrahydrofuran 071 043 041 042
Acetone Propanone 043 058 001 001
DCM Dichloromethane 049 084 086 051
DMA Dimethylacetamide 044 087 072 001
DMF Dimethylformamide 044 042 073 001
Ethanol Ethyl Alcohol 031 045 046 001
Ethyl Acetate Ethyl Acetate 043 045 061 070
Heptane Heptane 043 041 057 071
Isopropanol Isopropanol 045 043 041 059
Isopropyl Acetate Isopropyl Acetate 043 061 087 041
MeCN Acetonitrile 041 001 001 001
MEK 2-Butanone 043 072 057 001
Methanol Methyl Alcohol 031 032 029 001
MIBK Methyl Isobutyl Ketone 043 058 057 041
MTBE Methyl tertiary-butyl 057 073 001 001
NMP N-Methylpyrrolidone 042 057 084 085
THF Tetrahydrofuran 042 041 072 071
Toluene Toluene 091 092 001 001
Water Water 018 001 001 001

Real-Time Solvent Drying Monitoring with MAX300-BIO & MAX300-LG

The EXTREL™ MAX300-BIO™ and MAX300-LG™ quadrupole mass spectrometers from Process Insights deliver precise, real-time gas analysis for solvent drying and recovery processes. Designed for continuous monitoring of organic solvents and trace moisture, these analyzers provide critical data to optimize drying performance, maximize solvent recovery, and ensure process safety.

Capable of detecting a wide range of solvents such as IPA, MEK, DCM, ethyl acetate, styrene, and acetonitrile, the MAX300 series supports fast, multi-species analysis across multiple drying chambers and process streams. Whether in pharmaceutical production, chemical manufacturing, or materials processing, these analyzers help improve batch consistency, reduce cycle times, and minimize residual solvent levels.

Mass Spectrometer Benefits

  • Real-time analysis of multiple solvents and moisture
  • High sensitivity with ppb to percent-level detection
  • Supports ambient and vacuum drying conditions
  • Flexible stream switching for monitoring multiple chambers
  • Robust, low-maintenance design for 24/7 operation
  • Instantaneous results of all solvent concentrations during the recovery process
  • Monitor both continuous and batch distillation
  • Monitor adsorber saturation
  • Analyze multiple solvents
  • One analyzer may be coupled with other pharmaceutical applications (fermentation, solvent drying)

With the MAX300-BIO and MAX300-LG, manufacturers gain the visibility and control needed to streamline solvent drying, improve product quality, and meet regulatory standards with confidence.

Contact us today for more informaton.


Mass Spectrometers for accurate endpoint determination 

Solvent Drying & Recovery | Mass Spectrometer

MAX300-Bio Series Mass Spectrometer for
Real-Time, Multi-Stream, Solvent Drying
and Endpoint Determination

Solvent Drying & Recovery | Mass Spectrometer

MAX300-LG Benchtop Mass Spectrometer for
Real-Time, Multi-Stream, Solvent
Drying and Endpoint Determination


CRDS-Based Moisture Analysis for Solvent Drying & Recovery

The TIGER OPTICS™ HALO RP™ and HALO QRP™ are CRDS-based trace moisture analyzers best suited for low-pressure, water vapor detection (e.g., lyophilizers).

CRDS Trace-Level,
Low-Pressure Moisture
Analyzer for Lyophilization
HALO RP™ 

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HALO-QRP-2020_small-45eb7ead

CRDS Trace-Level,
Low-Pressure Moisture
Analyzer for Lyophilization
HALO QRP™