The MGA 1200CS™ is an advanced bioprocess gas analyzer engineered for real-time fermentation monitoring, cell culture monitoring, and bioreactor off-gas analysis. Unlike conventional CO₂/O₂ analyzers, the MGA 1200CS uses a fixed magnetic sector mass spectrometer to simultaneously analyze up to 16 gas components while automatically calculating Oxygen Uptake Rate (OUR), Carbon Dioxide Evolution Rate (CER), and Respiratory Quotient (RQ).
Designed for laboratory research, pilot plants, and commercial biomanufacturing, the MGA 1200CS delivers continuous process intelligence that improves yield, shortens development time, and supports Process Analytical Technology (PAT), Quality by Design (QbD), and automated process control.
Why Choose a Process Insights Process Mass Spectrometer?
Why Monitor Fermentation Off-Gas?
Real-time off-gas analysis provides direct insight into metabolic activity inside fermenters and bioreactors.
Continuous gas monitoring enables operators to:
- Optimize microbial fermentation
- Improve mammalian cell culture performance
- Detect metabolic changes immediately
- Optimize feeding strategies
- Increase product yields
- Reduce batch variability
- Improve scale-up success
- Support automated process control
- Eliminate delays associated with laboratory sampling
Why Choose the MGA 1200CS for Fermentation and Cell Culture Gas Measurements?
The MGA 1200CS is a high-performance gas analysis solution for fermentation and cell culture analysis, it delivers fast, accurate measurements of CO₂ and O₂ in real time, as well as other gases. Utilizing Fixed Magnetic Sector Mass Spectroscopy, the MGA provides the highest possible precision for fermentation and cell culture gas measurements.
Engineered for easy integration into industrial and lab-scale fermentation and cell culture systems, the MGA 1200CS features a robust, low-maintenance design which is ideal for Life Science Applications.
The MGA 1200 CS has best-in-class stability, with extended calibration intervals while providing the highest possible analytical precision.
Key Benefits
- Continuous online off-gas analysis
- Simultaneous measurement of up to 16 gases
- Automatic OUR calculation
- Automatic CER calculation
- Automatic Respiratory Quotient (RQ)
- Analyze up to 100 bioreactors from one analyzer
- New analytical data every 3 seconds
- Low-flow sampling down to 20 cc/min
- Ideal for bioreactors as small as 250 mL
- Best-in-class drift performance
- Long calibration intervals
- CyberSecure PLC architecture
- Native IIoT connectivity
These features distinguish the MGA 1200CS from conventional bioprocess gas analyzers that typically monitor only CO₂ and O₂.
Directly measure OUR, CER, and Respiratory Quotient (RQ) with the precision of magnetic sector mass spectrometry—even at ultra-low gas flow rates.
Exceptional Measurement Precision
- O₂ Standard Deviation: 0.002%
- CO₂ Standard Deviation: 0.009%
Flow Options
6–120 cc/min — Micro-scale & Single-Use Bioreactors (SUBs)
20–200 cc/min — Laboratory & Pilot Plant
70–700 cc/min — Pilot Plant & Production
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